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Science 24 April 1981:
Vol. 212. no. 4493, pp. 403 - 411
DOI: 10.1126/science.6163215
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Articles

Science, Vol 212, Issue 4493, 403-411
Copyright © 1981 by American Association for the Advancement of Science

articles

Secondary structure of 16S ribosomal RNA

HF Noller and CR Woese

A secondary structure model for 16S ribosomal RNA which is based on available chemical, enzymatic, and comparative sequence data shows good agreement between constraints dictated by the model and a wide variety of experimental observations. The four major structural domains created by the base-pairing scheme correspond closely to RNA fragments isolated after nuclease digestion in the presence of bound ribosomal proteins. Functionally important sites appear to be located in unpaired regions and are phylogenetically highly conserved.


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