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Science 17 April 1981:
Vol. 212. no. 4492, pp. 361 - 362
DOI: 10.1126/science.212.4492.361
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Articles

Genetic Evidence That Protein Synthesis Is Required for the Circadia Clock of Neurospora

HIDEAKI NAKASHIMA 1, JANINE PERLMAN 1, and JERRY F. FELDMAN 1

1 Thimann Laboratories, University of California, Santa Cruz 95064

Small doses of cycloheximide given at intervals (pulses) cause phase shifts of the circadian clock of Neurospora. The effects of this drug on the clock are mediated through its inhibition of protein synthesis, since two cycloheximide-resistant mutants whose 80S ribosomes are resistant to cycloheximide showed no phase shift after exposure to the durg.

Submitted on July 25, 1980
Revised on November 25, 1980


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cycloheximide Inhibits Light-Induced Phase Shifting of the Circadian Clock in Neurospora.
C. H. Johnson and H. Nakashima (1990)
J Biol Rhythms 5, 159-167
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Genetic and Molecular Analysis of Biological Rhythms.
J. C. Hall and M. Rosbash (1987)
J Biol Rhythms 2, 153-178
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Are Protein Synthesis Inhibition and Phase Shifting of the Circadian Clock in Gonyaulax Correlated?.
W. Olesiak, A. Ungar, C. H. Johnson, and J. W. Hastings (1987)
J Biol Rhythms 2, 121-138
   Abstract »    PDF »
Biochemical modeling of an autonomously oscillatory circadian clock in Euglena.
K Goto, D. Laval-Martin, and L. Edmunds Jr (1985)
Science 228, 1284-1288
   Abstract »    PDF »
Regulation of circadian rhythmicity.
J. Takahashi and M Zatz (1982)
Science 217, 1104-1111
   Abstract »    PDF »


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