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Science 17 April 1981:
Vol. 212. no. 4492, pp. 358 - 361
DOI: 10.1126/science.6259733
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Articles

Science, Vol 212, Issue 4492, 358-361
Copyright © 1981 by American Association for the Advancement of Science

articles

GABA analogues activate channels of different duration on cultured mouse spinal neurons

JL Barker and DA Mathers

Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to gamma-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations.


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