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Science 17 April 1981:
Vol. 212. no. 4492, pp. 340 - 341
DOI: 10.1126/science.7209534
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Articles

Science, Vol 212, Issue 4492, 340-341
Copyright © 1981 by American Association for the Advancement of Science

articles

Astatine-211--tellurium radiocolloid cures experimental malignant ascites

WD Bloomer, WH McLaughlin, RD Neirinckx, SJ Adelstein, PR Gordon, TJ Ruth, and AP Wolf

An investigation of the efficacy of astatine-211--tellurium colloid for the treatment of experimental malignant ascites in mice reveals that this alpha-emitting radiocolloid can be curative without causing undue toxicity to normal tissue. By comparison, negatron-emitting phosphorus-32 as colloidal chromic phosphate had no antineoplastic activity. The most compelling explanation for this striking difference is the dense ionization and short range of action associated with alpha-emission. These results have important implications for the development and use of alpha-emitters as radiocolloid therapy for the treatment of human tumors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High-Level Production of {alpha}-Particle-Emitting 211At and Preparation of 211At-Labeled Antibodies for Clinical Use.
M. R. Zalutsky, X.-G. Zhao, K. L. Alston, and D. Bigner (2001)
J. Nucl. Med. 42, 1508-1515
   Abstract »    Full Text »    PDF »
Overcoming the Obstacles to Clinical Evaluation of 211At-Labeled Radiopharmaceuticals.
D. S. Wilbur (2001)
J. Nucl. Med. 42, 1516-1518
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High and Low Fluences of {{alpha}}-Particles Induce a G1 Checkpoint in Human Diploid Fibroblasts.
E. I. Azzam, S. M. de Toledo, A. J. Waker, and J. B. Little (2000)
Cancer Res. 60, 2623-2631
   Abstract »    Full Text »
Radioimmunotherapy with alpha-particle-emitting immunoconjugates.
R. Macklis, B. Kinsey, A. Kassis, J. Ferrara, R. Atcher, J. Hines, C. Coleman, S. Adelstein, and S. Burakoff (1988)
Science 240, 1024-1026
   Abstract »    PDF »


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