Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 3 April 1981:
Vol. 212. no. 4490, pp. 81 - 83
DOI: 10.1126/science.7193909
Prev | Table of Contents | Next

Articles

Science, Vol 212, Issue 4490, 81-83
Copyright © 1981 by American Association for the Advancement of Science

articles

Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats

JD Davis, D Wirtshafter, KE Asin, and D Brief

Long-term infusion of glucose, beta-hydroxybutyrate, and glycerol into the third ventricle of the rat brain caused a stabilization of body weight at a lower than normal level. Among the glucose- and glycerol-treated animals this weight loss was caused in part by temporary hypophagia. Among the animals treated with beta-hydroxybutyrate the weight loss was unaccompanied by a reduction in food intake. The results are consistent with the view that the systems controlling food intake and body weight are sensitive to the availability of brain fuels. They are not consistent however, with the view that these control systems monitor calories independently of their source.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diet-derived nutrients mediate the inhibition of hypothalamic NPY neurons in the arcuate nucleus of mice during refeeding.
C. Becskei, T. A. Lutz, and T. Riediger (2009)
Am J Physiol Regulatory Integrative Comp Physiol 297, R100-R110
   Abstract »    Full Text »    PDF »
CNS Regulation of Glucose Homeostasis.
C. K. L. Lam, M. Chari, and T. K. T. Lam (2009)
Physiology 24, 159-170
   Abstract »    Full Text »    PDF »
Dietary carbohydrates induce changes in glucosensing capacity and food intake of rainbow trout.
S. Polakof, J. M. Miguez, and J. L. Soengas (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R478-R489
   Abstract »    Full Text »    PDF »
Central lactate metabolism regulates food intake.
C. K. L. Lam, M. Chari, P. Y. T. Wang, and T. K. T. Lam (2008)
Am J Physiol Endocrinol Metab 295, E491-E496
   Abstract »    Full Text »    PDF »
Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?.
P. D. Mountjoy and G. A. Rutter (2007)
Exp Physiol 92, 311-319
   Abstract »    Full Text »    PDF »
Pancreatic signals controlling food intake; insulin, glucagon and amylin.
S. C Woods, T. A Lutz, N. Geary, and W. Langhans (2006)
Phil Trans R Soc B 361, 1219-1235
   Abstract »    Full Text »    PDF »
Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic-Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus.
C. Fekete, P. S. Singru, E. Sanchez, S. Sarkar, M. A. Christoffolete, R. S. Riberio, W. M. Rand, C. H. Emerson, A. C. Bianco, and R. M. Lechan (2006)
Endocrinology 147, 520-529
   Abstract »    Full Text »    PDF »
Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism.
T. K. T. Lam, R. Gutierrez-Juarez, A. Pocai, and L. Rossetti (2005)
Science 309, 943-947
   Abstract »    Full Text »    PDF »
Role of Neuronal Energy Status in the Regulation of Adenosine 5'-Monophosphate-Activated Protein Kinase, Orexigenic Neuropeptides Expression, and Feeding Behavior.
K. Lee, B. Li, X. Xi, Y. Suh, and R. J. Martin (2005)
Endocrinology 146, 3-10
   Abstract »    Full Text »    PDF »
Neuronal Glucosensing: What Do We Know After 50 Years?.
B. E. Levin, V. H. Routh, L. Kang, N. M. Sanders, and A. A. Dunn-Meynell (2004)
Diabetes 53, 2521-2528
   Abstract »    Full Text »    PDF »
Current and Potential Drugs for Treatment of Obesity.
G. A. Bray and F. L. Greenway (1999)
Endocr. Rev. 20, 805-875
   Abstract »    Full Text »
Brain glucose sensing and body energy homeostasis: role in obesity and diabetes.
B. E. Levin, A. A. Dunn-Meynell, and V. H. Routh (1999)
Am J Physiol Regulatory Integrative Comp Physiol 276, R1223-R1231
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)