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Science 27 March 1981:
Vol. 211. no. 4489, pp. 1441 - 1444
DOI: 10.1126/science.6162200
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Articles

Science, Vol 211, Issue 4489, 1441-1444
Copyright © 1981 by American Association for the Advancement of Science

articles

F-cell production in sickle cell anemia: regulation by genes linked to beta-hemoglobin locus

GJ Dover, SH Boyer, and ME Pembrey

Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin.
J. Old, H Ayyub, W. Wood, J. Clegg, and D. Weatherall (1982)
Science 215, 981-982
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