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Science 27 March 1981:
Vol. 211. no. 4489, pp. 1439 - 1441
DOI: 10.1126/science.7466402
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Articles

Science, Vol 211, Issue 4489, 1439-1441
Copyright © 1981 by American Association for the Advancement of Science

articles

Fluorocarbons reduce myocardial ischemic damage after coronary occlusion

DH Glogar, RA Kloner, J Muller, LW DeBoer, E Braunwald, and LC Clark Jr

Open-chest, anesthetized dogs with occlusions of the left anterior descending coronary artery breathed 100 percent oxygen while they were bled to a hematocrit of 25 percent and infused with an approximately equal volume (40 milliliters per kilogram) of fluorocarbon preparation or Ringer solution. Dogs breathing room air and receiving no treatment served as controls. After undergoing 6 hours of coronary occlusion, animals bled and treated with fluorocarbons developed smaller infarctions than those receiving Ringer solution or no treatment.


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