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Science 27 March 1981:
Vol. 211. no. 4489, pp. 1433 - 1435
DOI: 10.1126/science.6781068
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Articles

Science, Vol 211, Issue 4489, 1433-1435
Copyright © 1981 by American Association for the Advancement of Science

articles

Molecular basis of bunyavirus transmission by mosquitoes: role of the middle-sized RNA segment

BJ Beaty, M Holterman, W Tabachnick, RE Shope, EJ Rozhon, and DH Bishop

In an examination of the molecular basis of oral transmission of bunyaviruses by mosquitoes., La Crosse (LAC), snowshoe hare (SSH), and LAC-SSH reassortant viruses were compared in their ability to be transmitted to laboratory mice by the natural mosquito vector of LAC virus, Aedes triseriatus. Both LAC virus and the reassortment viruses containing the middle-sized (M) segment from the LAC parent were efficiently transmitted. In contrast, SSH virus and reassortment viruses containing the M RNA from the SSH parent were inefficiently transmitted. Thus, the M RNA segment, which codes for the virion glycoproteins, may be a major determinant of oral transmission of bunyaviruses by mosquitoes.


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Bunyavirus superinfection and segment reassortment in transovarially infected mosquitoes.
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Evolution of bunyaviruses by genome reassortment in dually infected mosquitoes (Aedes triseriatus).
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