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Science 27 March 1981:
Vol. 211. no. 4489, pp. 1429 - 1431
DOI: 10.1126/science.7466399
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Articles

Science, Vol 211, Issue 4489, 1429-1431
Copyright © 1981 by American Association for the Advancement of Science

articles

Aspirin prevention of cholesterol gallstone formation in prairie dogs

SP Lee, MC Carey, and JT LaMont

When prairie dogs (Cynomys ludovicianus) are fed a diet containing cholesterol, a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile. Gelation of mucin precedes the precipitation of cholesterol liquid and solid crystals and the development of gallstones. Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile. This suggests that gallbladder mucin is a nucleation matrix for cholesterol gallstones.


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Increased sphincter of Oddi basal pressure in patients affected by gall stone disease: a role for biliary stasis and colicky pain?.
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Pathogenesis and Treatment of Gallstones.
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Evaluation of Prostacyclin Production by Human Gallbladder.
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Effects of Female Sex Hormones and Pregnancy on Gallbladder Prostaglandin Synthesis.
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Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice.
H. Wittenburg, F. Lammert, D. Q.-H. Wang, G. A. Churchill, R. Li, G. Bouchard, M. C. Carey, and B. Paigen (2002)
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