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Science 13 March 1981:
Vol. 211. no. 4487, pp. 1187 - 1189
DOI: 10.1126/science.7466393
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Articles

Science, Vol 211, Issue 4487, 1187-1189
Copyright © 1981 by American Association for the Advancement of Science

articles

Dye transfer through gap junctions between neuroendocrine cells of rat hypothalamus

RD Andrew, BA MacVicar, FE Dudek, and GI Hatton

Most magnocellular neurosecretory cells that terminate in the posterior pituitary secrete either vasopressin, oxytocin, or enkephalin. Intracellular injection of the fluorescent dye Lucifer Yellow into single magnocellular neurons in slices of rat hypothalamus resulted in dye transfer between these cells. Freeze-fracture replicas of these cells occasionally revealed gap junctions, which presumably contain channels that mediate the dye coupling. These two independent techniques strongly suggest that some mammalian neuropeptidergic cells are electrotonically coupled, providing a possible means for recruitment and synchronization of their electrical activity.


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