Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 March 1981:
Vol. 211. no. 4487, pp. 1183 - 1185
DOI: 10.1126/science.6258229
Prev | Table of Contents | Next

Articles

Science, Vol 211, Issue 4487, 1183-1185
Copyright © 1981 by American Association for the Advancement of Science

articles

Imipramine: effect of ovarian steroids on modifications in serotonin receptor binding

DA Kendall, GM Stancel, and SJ Enna

Long-term administration of imipramine caused a decrease in serotonin2 receptor binding in rat brain cerebral cortex, an effect that was abolished by ovariectomy. In contrast, ovariectomy had no effect on imipramine-induced decreases in hippocampal serotonin or in cerebral cortical and hippocampal beta-adrenergic receptor binding. Administration of estradiol or progesterone separately or in combination reestablished the effect of imipramine treatment on cortical serotonin2 receptors. These results suggest that ovarian steroids may play an important, but subtle, role in the neurochemical and perhaps clinical response to this drug.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gonadal Steroids in the Treatment of Mood Disorders.
C. N. Epperson, K. L. Wisner, and B. Yamamoto (1999)
Psychosom Med 61, 676-697
   Abstract »    Full Text »    PDF »
The Psychoendocrinology of Menopause in Cross-Cultural Perspective.
D. A. Charney (1996)
Transcultural Psychiatry 33, 413-434
   Abstract »    PDF »
The Psychobiology of Female Aggression.
D. H. FISHBEIN (1992)
Criminal Justice and Behavior 19, 99-126
   Abstract »
Hooked on Hormones? An Anabolic Steroid Addiction Hypothesis.
K. B. Kashkin and H. D. Kleber (1989)
JAMA 262, 3166-3170
   Abstract »    PDF »
Induced expression of the glucocorticoid receptor in the rat intermediate pituitary lobe.
T Antakly, A Sasaki, A. Liotta, M Palkovits, and D. Krieger (1985)
Science 229, 277-279
   Abstract »    PDF »
Sex differences in serotonin 1 receptor binding in rat brain.
C. Fischette, A Biegon, and B. McEwen (1983)
Science 222, 333-335
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)