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Science 13 March 1981:
Vol. 211. no. 4487, pp. 1175 - 1177
DOI: 10.1126/science.7466390
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Articles

Science, Vol 211, Issue 4487, 1175-1177
Copyright © 1981 by American Association for the Advancement of Science

articles

Trisomic hemopoietic stem cells of fetal origin restore hemopoiesis in lethally irradiated mice

EW Herbst, DH Pluznik, A Gropp, and H Uthgennant

Autosomal trisomy in the mouse is invariably associated with fetal or early postnatal death. Hemopoietic stem cells from fetuses trisomic for chromosome 12 or 19 can be rescued by transplantation into lethally irradiated mice. These trisomic cells restore hemopoiesis, including lymphopoiesis, in the irradiated mice and establish a permanent and almost complete engraftment. There is no evidence that hemopoietic cells with trisomy 12 or 19 are cytogenetically unstable.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mice Triallelic for the Ig Heavy Chain Locus: Implications for VHDJH Recombination.
V. Barreto, T. Meo, and A. Cumano (2001)
J. Immunol. 166, 5638-5645
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