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Science 13 March 1981:
Vol. 211. no. 4487, pp. 1173 - 1175
DOI: 10.1126/science.7466389
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Articles

Science, Vol 211, Issue 4487, 1173-1175
Copyright © 1981 by American Association for the Advancement of Science

articles

Spontaneous hypertension ion cross-suckled rats

JP McMurtry, GL Wright, and BC Wexler

Genetically normotensive Sprague-Dawley rats nursed by spontaneously hypertensive foster mothers develop sustained high blood pressure. Some factor related to the genetically programmed hypertension of the foster mother is probably transmitted to the infant rats through her milk. Alternatively, the hyperkinetic behavior of the mother may activate a hypertensinogen in young having the proper constellation of genes.


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Current Perspectives on the Use of Gene Therapy for Hypertension.
C. H. Gelband, M. J. Katovich, and M. K. Raizada (2000)
Circ. Res. 87, 1118-1122
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Permanent Cardiovascular Protection From Hypertension by the AT1 Receptor Antisense Gene Therapy in Hypertensive Rat Offspring.
P. Y. Reaves, C. H. Gelband, H. Wang, H. Yang, D. Lu, K. H. Berecek, M. J. Katovich, and M. K. Raizada (1999)
Circ. Res. 85 , e44-e50
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Ontogenetic Aspects of Hypertension Development: Analysis in the Rat.
J. Zicha and J. Kunes (1999)
Physiol Rev 79, 1227-1282
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