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Science 13 March 1981:
Vol. 211. no. 4487, pp. 1164 - 1166
DOI: 10.1126/science.7466386
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Articles

Science, Vol 211, Issue 4487, 1164-1166
Copyright © 1981 by American Association for the Advancement of Science

articles

Conversion of 3T3-L1 fibroblasts to fat cells by an inhibitor of methylation: effect of 3-deazaadenosine

PK Chiang

3-Deazaadenosine, an inhibitor of methylation, increased the frequency of conversion of 3T3-L1 fibroblasts to fat cells in a dose-dependent manner. Once converted, the 3T3-L1 fat cells retained their adipose morphology and accumulated triglycerides even when 3-deazaadenosine was removed from the culture medium. 3-Deazaadenosine may perturb cellular methylation and thereby lead to an increase in the frequency of differentiation of 3T3-L1 fibroblasts to fat cells.


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