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Science 6 March 1981:
Vol. 211. no. 4486, pp. 1072 - 1074
DOI: 10.1126/science.6110244
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Articles

Science, Vol 211, Issue 4486, 1072-1074
Copyright © 1981 by American Association for the Advancement of Science

articles

Paradoxical elevation of growth hormone by intraventricular somatostatin: possible ultrashort-loop feedback

MD Lumpkin, A Gegro-Vilar, and SM McCann

Somatostatin, the growth hormone-inhibiting factor, when microinjected into the third ventricle of the rat brain, paradoxically induced the release of growth hormone. A pituitary site of action having been ruled out, this result supports the concept that exogenous somatostatin within the hypothalamus acts either to suppress the release of somatostatin from somatostatin-containing neurons, possibly via an ultrashort-loop feedback mechanism, or to augment release of hypothalamic growth hormone-releasing factor, thereby inducing a release of growth hormone. Injection of somatostatin into the third ventricle also decreased plasma concentrations of luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone, probably by inhibiting the release of luteinizing hormone-releasing factor and thyrotropin-releasing factor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gender-Dependent Role of Endogenous Somatostatin in Regulating Growth Hormone-Axis Function in Mice.
R. M. Luque and R. D. Kineman (2007)
Endocrinology 148, 5998-6006
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Model-projected mechanistic bases for sex differences in growth hormone regulation in humans.
L. S. Farhy, C. Y. Bowers, and J. D. Veldhuis (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1577-R1593
   Abstract »    Full Text »    PDF »
Regulation by Estradiol of Hypothalamic Somatostatin Gene Expression: Possible Involvement of Somatostatin in the Control of Luteinizing Hormone Secretion in the Ewe.
D. Pillon, A. Caraty, C. Fabre-Nys, D. Lomet, M. Cateau, and G. Bruneau (2004)
Biol Reprod 71, 38-44
   Abstract »    Full Text »    PDF »
Putative GH pulse renewal: periventricular somatostatinergic control of an arcuate-nuclear somatostatin and GH-releasing hormone oscillator.
L. S. Farhy and J. D. Veldhuis (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R1030-R1042
   Abstract »    Full Text »    PDF »
Involvement of the Sst1 Somatostatin Receptor Subtype in the Intrahypothalamic Neuronal Network Regulating Growth Hormone Secretion: An in Vitro and in Vivo Antisense Study.
C. Lanneau, M. T. Bluet-Pajot, P. Zizzari, Z. Csaba, P. Dournaud, L. Helboe, D. Hoyer, E. Pellegrini, G. S. Tannenbaum, J. Epelbaum, et al. (2000)
Endocrinology 141, 967-979
   Abstract »    Full Text »    PDF »
Neuroendocrine Control of Growth Hormone Secretion.
E. E. Muller, V. Locatelli, and D. Cocchi (1999)
Physiol Rev 79, 511-607
   Abstract »    Full Text »    PDF »
Immunohistochemical and Cytochemical Localization of the Somatostatin Receptor Subtype sst1 in the Somatostatinergic Parvocellular Neuronal System of the Rat Hypothalamus.
L. Helboe, C. E. Stidsen, and M. Moller (1998)
J. Neurosci. 18, 4938-4945
   Abstract »    Full Text »    PDF »
Arginine vasopressin as a thyrotropin-releasing hormone.
M. Lumpkin, W. Samson, and S. McCann (1987)
Science 235, 1070-1073
   Abstract »    PDF »
Growth hormone-releasing factor: direct effects on growth hormone, glucose, and behavior via the brain.
G. Tannenbaum (1984)
Science 226, 464-466
   Abstract »    PDF »
Dementia in the Elderly: The Silent Epidemic.
J. C. BECK, D. F. BENSON, A. B. SCHEIBEL, J. E. SPAR, and L. Z. RUBENSTEIN (1982)
Ann Intern Med 97, 231-241
   Abstract »    PDF »


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