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Science 27 February 1981:
Vol. 211. no. 4485, pp. 955 - 957
DOI: 10.1126/science.7466370
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Articles

Science, Vol 211, Issue 4485, 955-957
Copyright © 1981 by American Association for the Advancement of Science

articles

Essential hypertension: central and peripheral norepinephrine

CR Lake, HG Gullner, RJ Polinsky, MH Ebert, MG Ziegler, and FC Bartter

The concentration of norepinephrine in cerebrospinal fluid from patients with essential hypertension is higher than that from healthy normal volunteers, but the concentrations of norepinephrine in plasma from these groups are similar. This finding indicates that central nervous system noradrenergic hyperactivity occurs in essential hypertension but apparently is not reflected in abnormal function of the peripheral sympathetic nervous system in these patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Blood Pressure and Cerebrospinal Fluid Norepinephrine in Combat-Related Posttraumatic Stress Disorder.
J. R. Strawn, N. N. Ekhator, P. S. Horn, D. G. Baker, and T. D. Geracioti Jr. (2004)
Psychosom Med 66, 757-759
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Central noradrenergic pathways for the integration of hypothalamic neuroendocrine and autonomic responses.
P. Sawchenko and L. Swanson (1981)
Science 214, 685-687
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Cerebroventricular propranolol elevates cerebrospinal fluid norepinephrine and lowers blood pressure.
R. Tackett, J. Webb, and P. Privitera (1981)
Science 213, 911-913
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