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Science 27 February 1981:
Vol. 211. no. 4485, pp. 947 - 949
DOI: 10.1126/science.7008195
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Articles

Science, Vol 211, Issue 4485, 947-949
Copyright © 1981 by American Association for the Advancement of Science

articles

Insulin as a potent, specific growth factor in a rat hepatoma cell line

JW Koontz and M Iwahashi

A line or rat hepatoma cells in culture which, in response to serum starvation, become arrested in the early G1 phase of growth, can be stimulated by insulin alone to enter the cell cycle and traverse S phase. A half-maximum response is observed at 30 to 70 picomolar concentrations and the maximum response is essentially identical to that found with optimum serum concentrations.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma.
K Saito, S Inoue, T Saito, S Kiso, N Ito, S Tamura, H Watanabe, H Takeda, H Misawa, H Togashi, et al. (2002)
Gut 51, 100-104
   Abstract »    Full Text »    PDF »
Effects of Dichloroacetate (DCA) on Serum Insulin Levels and Insulin-Controlled Signaling Proteins in Livers of Male B6C3F1 Mice.
M. K. Lingohr, B. D. Thrall, and R. J. Bull (2001)
Toxicol. Sci. 59, 178-184
   Abstract »    Full Text »    PDF »
Insulin-induced Early Growth Response Gene (Egr-1) Mediates a Short Term Repression of Rat Malic Enzyme Gene Transcription.
I. Barroso and P. Santisteban (1999)
J. Biol. Chem. 274, 17997-18004
   Abstract »    Full Text »    PDF »
Functional Association between the Insulin Receptor and the Transmembrane Protein-tyrosine Phosphatase LAR in Intact Cells.
F. Ahmad and B. J. Goldstein (1997)
J. Biol. Chem. 272, 448-457
   Abstract »    Full Text »    PDF »
Thyrotropin via Cyclic AMP Induces Insulin Receptor Expression and Insulin Co-stimulation of Growth and Amplifies Insulin and Insulin-like Growth Factor Signaling Pathways in Dog Thyroid Epithelial Cells.
R. Burikhanov, K. Coulonval, I. Pirson, F. Lamy, J. E. Dumont, and P. P. Roger (1996)
J. Biol. Chem. 271, 29400-29406
   Abstract »    Full Text »    PDF »
Cloning and Characterization of a Functional Promoter of the Rat pp120 Gene, Encoding a Substrate of the Insulin Receptor Tyrosine Kinase.
S. M. Najjar, Y. R. Boisclair, Z. T. Nabih, N. Philippe, Y. Imai, Y. Suzuki, D.-S. Suh, and G. T. Ooi (1996)
J. Biol. Chem. 271, 8809-8817
   Abstract »    Full Text »    PDF »
Osmotic Loading of Neutralizing Antibodies Demonstrates a Role for Protein-tyrosine Phosphatase 1B in Negative Regulation of the Insulin Action Pathway.
F. Ahmad, P.-M. Li, J. Meyerovitch, and B. J. Goldstein (1995)
J. Biol. Chem. 270, 20503-20508
   Abstract »    Full Text »    PDF »
The generation of insulin-like growth factor-1--sensitive cells by growth hormone action.
K. Zezulak and H Green (1986)
Science 233, 551-553
   Abstract »    PDF »


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