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Science 20 February 1981:
Vol. 211. no. 4484, pp. 844 - 846
DOI: 10.1126/science.7466362
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Articles

Science, Vol 211, Issue 4484, 844-846
Copyright © 1981 by American Association for the Advancement of Science

articles

Exercise hyperpnea and locomotion: parallel activation from the hypothalamus

FL Eldridge, DE Millhorn, and TG Waldrop

Unanesthetized decorticate cats walked or ran normally on a treadmill either spontaneously or during electrical stimulation of the subthalamic "locomotor" region. The respiratory response usually preceded the locomotor response and increased in proportion to locomotor activity despite control or ablation of respiratory feedback mechanisms. Respiration increased similarly in paralyzed animals during fictive locomotion despite the absence of muscular contraction or movement. Hypothalamic command signals are thus primarily responsible for the proportional driving of locomotion and respiration during exercise.


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Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans.
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J. Physiol. 539, 615-621
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Short-term modulation of the exercise ventilatory response in goats: effects of 8-OH-DPAT and MPPI.
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Reconfiguration of the Respiratory Network at the Onset of Locust Flight.
J.-M. Ramirez (1998)
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Augmented renal sympathetic nerve activity by central command during overground locomotion in decerebrate cats.
K. Matsukawa, J. Murata, and T. Wada (1998)
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