Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 February 1981:
Vol. 211. no. 4482, pp. 595 - 597
DOI: 10.1126/science.7455700
Prev | Table of Contents | Next

Articles

Science, Vol 211, Issue 4482, 595-597
Copyright © 1981 by American Association for the Advancement of Science

articles

Neurosecretory granules: evidence from an aging process within the neurohypophysis

JJ Nordmann and J Labouesse

When cysteine labeled with sulfur-35 is injected into the third ventricle of the rat brain, it is first incorporated into only one of the two populations of neurosecretory granules that can be isolated on an isosmotic gradient. The second population of granules is labeled much later. Stimulation of hormone release from isolated labeled neural lobes and subsequent isolation of neurosecretory granules at different times after the injection of labeled cysteine shows that the radioactivity decreases in only one population of granules. One of the fractions of the gradient represents the granules found near the release site; the second population is probably located deeper in the nerve endings or in the nerve swellings. Whereas neurophysins are found in both populations, smaller proteins can only be detected in one. Thus it appears that neurosecretory granules undergo an aging process and that isosmotic gradients can separate the aged granules from those newly formed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dietary Exposure to Aroclor 1254 Alters Central and Peripheral Vasopressin Release in Response to Dehydration in the Rat.
C. G. Coburn, E. R. Gillard, and M. C. Curras-Collazo (2005)
Toxicol. Sci. 84, 149-156
   Abstract »    Full Text »    PDF »
The Enkephalinergic Neuron: Implications of a Polyenkephalin Precursor.
J. Rossier, D. Liston, G. Patey, M. Chaminade, A.S. Foutz, A. Cupo, P. Giraud, M.P. Roisin, J.P. Henry, P. Verbanck, et al. (1983)
Cold Spring Harb Symp Quant Biol 48, 393-404
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)