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Science 30 January 1981:
Vol. 211. no. 4481, pp. 487 - 489
DOI: 10.1126/science.7455688
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Articles

Science, Vol 211, Issue 4481, 487-489
Copyright © 1981 by American Association for the Advancement of Science

articles

Therapy of mouse lymphoma with monoclonal antibodies to glycolipid: selection of low antigenic variants in vivo

WW Young Jr and SI Hakomori

Growth of mouse lymphoma L5178Y, which contains large quantitites of the gangliotriosylceramide (GgOs3Cer), in DBA/2 mice was suppressed by passive immunization with monoclonal immunoglobulin G3 antibodies to GgOS3Cer, but not by immunoglobulin M antibodies with or without added complement. Most groups of mice treated with monoclonal immunoglobulin G3 antibodies did not develop tumors, but the tumor that appeared in a treated animal had a much lower amount of the GgOS3Cer than the cells used for inoculation. Thus, passive immunization either prevented growth of the lymphoma or caused selection of a variant with a lower quantity of the antigen GgOS3Cer.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody.
E Nudelman, R Kannagi, S Hakomori, M Parsons, M Lipinski, J Wiels, M Fellous, and T Tursz (1983)
Science 220, 509-511
   Abstract »    PDF »
Transplantation of leukemic bone marrow treated with cytotoxic antileukemic antibodies and complement.
M. Trigg and D. Poplack (1982)
Science 217, 259-261
   Abstract »    PDF »
Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies.
D. Scheinberg, M Strand, and O. Gansow (1982)
Science 215, 1511-1513
   Abstract »    PDF »


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