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Science 23 January 1981:
Vol. 211. no. 4480, pp. 400 - 402
DOI: 10.1126/science.6164096
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Articles

Science, Vol 211, Issue 4480, 400-402
Copyright © 1981 by American Association for the Advancement of Science

articles

Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus

MR Lerner, JA Boyle, JA Hardin, and JA Steitz

The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.


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Activities of adenovirus virus-associated RNAs: Purification and characterization of RNA binding proteins.
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M Phase Phosphoprotein 10 Is a Human U3 Small Nucleolar Ribonucleoprotein Component.
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Lupus 5, 263-268
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The Autoantibody Response to Ro/SSA in Cutaneous Lupus Erythematosus.
L. A. Lee, C. M. Roberts, M. B. Frank, V. R. McCubbin, and M. Reichlin (1994)
Arch Dermatol 130, 1262-1268
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Sjogren's Syndrome and Infectious Mononucleosis.
B. J. MURRAY (1985)
Ann Intern Med 103, 161
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Immunobiological Significance of the Ro/SSA Antigen-Antibody System.
R. D. Sontheimer (1985)
Arch Dermatol 121, 327-330
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Neonatal Lupus Erythematosus.
A. T. Lane and R. M. Watson (1984)
Arch Pediatr Adolesc Med 138, 663-666
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Commentary: Neonatal Lupus Erythematosus.
T. T. Provost (1983)
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Small Ribonucleoproteins from Eukaryotes: Structures and Roles in RNA Biogenesis.
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Serologic and HLA Associations in Subacute Cutaneous Lupus Erythematosus, a Clinical Subset of Lupus Erythematosus.
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Ann Intern Med 97, 664-671
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La Autoantigen Is Cleaved in the COOH Terminus and Loses the Nuclear Localization Signal during Apoptosis.
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From the Cover: Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization.
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