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Science 16 January 1981:
Vol. 211. no. 4479, pp. 294 - 297
DOI: 10.1126/science.7444469
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Articles

Science, Vol 211, Issue 4479, 294-297
Copyright © 1981 by American Association for the Advancement of Science

articles

Giant synaptic potential hypothesis for epileptiform activity

D Johnston and TH Brown

According to one hypothesis, the paroxysmal depolarizing shift observed in the penicillin model of epilepsy results from a giant excitatory postsynaptic potential. This hypothesis has recently been questioned, primarily because it has never been subjected to rigorous experimental examination. Four quantitative predictions were derived from this hypothesis and tested in CA3 pyramidal neurons of the hippocampus. The four critical predictions concern the behavior of the paroxysmal depolarizing shift under current- and voltage-clamp conditions as a function of membrane potential. The experiments confirmed all four predictions.


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