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Science 2 January 1981:
Vol. 211. no. 4477, pp. 74 - 76
DOI: 10.1126/science.7444450
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Articles

Science, Vol 211, Issue 4477, 74-76
Copyright © 1981 by American Association for the Advancement of Science

articles

Immunophagocytic properties of retinal pigment epithelium cells

VM Elner, T Schaffner, K Taylor, and S Glagov

Retinal pigment cells were dislodged from normal monkey eyes and incubated in glass-slide chambers. All viable pigment cells adhered strongly to glass. They demonstrated surface receptors for the Fc portion of immunoglobulin G and for the third component of complement by selectively binding and phagocytizing antibody or complement-coated erythrocytes. These phagocytic cells with receptors were identified as retinal pigment cells by characteristic ultrastructural features. Thus, retinal pigment cells, which are generally believed to be derived from neural tissue, are not only scavengers of photoreceptor cell debris, but also have surface receptors and phagocytic functions that may be important in ocular defense.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
TLR4 Mediates Human Retinal Pigment Epithelial Endotoxin Binding and Cytokine Expression.
S. G. Elner, H. R. Petty, V. M. Elner, A. Yoshida, Z.-M. Bian, D. Yang, and A. L. Kindzelskii (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4627-4633
   Abstract »    Full Text »    PDF »
Novel Role for a Complement Regulatory Protein (CD46) in Retinal Pigment Epithelial Adhesion.
B. J. McLaughlin, W. Fan, J. J. Zheng, H. Cai, L. V. Del Priore, N. S. Bora, and H. J. Kaplan (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3669-3674
   Abstract »    Full Text »    PDF »
The Interphotoreceptor Matrix Mediates Primate Retinal Adhesion.
G. S. Hageman, M. F. Marmor, X. Y. Yao, and L. V. Johnson (1995)
Arch Ophthalmol 113, 655-660
   Abstract »    PDF »
In Situ Characterization of the Human Hyalocyte.
H. S. Lazarus and G. S. Hageman (1994)
Arch Ophthalmol 112, 1356-1362
   Abstract »    PDF »
An Antimelanoma Monoclonal Antibody and the Histopathology of Uveal Melanomas.
R. Folberg, L. A. Donoso, B. F. Atkinson, C. S. Ernst, M. Herlyn, and V. V. Arbizo (1985)
Arch Ophthalmol 103, 275-279
   Abstract »    PDF »


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