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Science 2 January 1981:
Vol. 211. no. 4477, pp. 65 - 67
DOI: 10.1126/science.6934621
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Articles

Science, Vol 211, Issue 4477, 65-67
Copyright © 1981 by American Association for the Advancement of Science

articles

Differentiation of murine bone marrow stem cells in vitro: long-term growth promoted by a lymphocyte-derived mediator

A Altman, TD Gilmartin, and DH Katz

In attempts to induce differentiation of lymphoid cells from hematopoietic stem cells in vitro, the effects of allogeneic effect factor on the growth of murine bone marrow cultures were studied. Allogeneic effect factor is a soluble mediator derived from mixed secondary murine leukocyte cultures. For several weeks it supported the growth of bone marrow cultures, as indicated by the maintenance of stem cell activity, cellular proliferation, and heterogeneity. Another lymphokine, T cell growth factor, did not, Pre-T lymphocytes could be detected in these cultures for several weeks.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)