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Science 2 January 1981:
Vol. 211. no. 4477, pp. 63 - 65
DOI: 10.1126/science.6255563
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Articles

Science, Vol 211, Issue 4477, 63-65
Copyright © 1981 by American Association for the Advancement of Science

articles

Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine

FR Maxfield, MC Willingham, I Pastan, P Dragsten, and SY Cheng

A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. Video intensification fluorescence microscopy indicates that binding occurs at the plasma membrane. Diffusion coefficients, obtained by fluorescence photobleaching recovery, are consistent with binding to a protein receptor on the cell surface.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Journey to the center of the cell: role of the receptosome.
I. Pastan and M. Willingham (1981)
Science 214, 504-509
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