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Science 19 December 1980:
Vol. 210. no. 4476, pp. 1372 - 1373
DOI: 10.1126/science.7434032
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Articles

Science, Vol 210, Issue 4476, 1372-1373
Copyright © 1980 by American Association for the Advancement of Science

articles

Pineal melatonin rhythm: reduction in aging Syrian hamsters

RJ Reiter, BA Richardson, LY Johnson, BN Ferguson, and DT Dinh

The melatonin content measured by radioimmunoassay of the pineal gland over a 24-hour period (a light:dark cycle of 14 hours of light and 10 of darkness) was compared in young and old female and male Syrian hamsters. The young animals of both sexes exhibited roughly an eightfold rise in pineal melatonin during the dark phase of the cycle, whereas in the old hamsters the nocturnal rise in melatonin was almost completely absent. The results indicate a marked drop in pineal biosynthetic activity in the aging hamster.


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