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Science 19 December 1980:
Vol. 210. no. 4476, pp. 1369 - 1371
DOI: 10.1126/science.6449080
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Articles

Science, Vol 210, Issue 4476, 1369-1371
Copyright © 1980 by American Association for the Advancement of Science

articles

Mental symptoms in Huntington's disease and a possible primary aminergic neuron lesion

JJ Mann, M Stanley, S Gershon, and M Rossor

Monoamine oxidase activity was higher in the cerebral cortex and basal ganglia of patients dying from Huntington's disease than in controls. Enzyme kinetics and multiple substrate studies indicated that the increased activity was due to elevated concentrations of monoamine oxidase type B. Concentrations of homovanillic acid were increased in the cerebral cortex but not in the basal ganglia of brains of patients with Huntington's disease. These changes may represent a primary aminergic lesion that could underlie some of the mental symptoms of this disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Monoamine Oxidase and Criminality: Identifying an Apparent Biological Marker for Antisocial Behavior.
L. ELLIS (1991)
Journal of Research in Crime and Delinquency 28, 227-251
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Regional brain concentrations of neuropeptides in Huntington's chorea and schizophrenia.
C. Nemeroff, W. Youngblood, P. Manberg, A. Prange Jr, and J. Kizer (1983)
Science 221, 972-975
   Abstract »    PDF »
Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
D. van Kammen, L. Mann, D. Sternberg, M Scheinin, P. Ninan, Marder SR, W. van Kammen, R. Rieder, and M Linnoila (1983)
Science 220, 974-977
   Abstract »    PDF »


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