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Science 12 December 1980:
Vol. 210. no. 4475, pp. 1269 - 1271
DOI: 10.1126/science.6254155
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Articles

Science, Vol 210, Issue 4475, 1269-1271
Copyright © 1980 by American Association for the Advancement of Science

articles

Glucose suppresses basal firing and haloperidol-induced increases in the firing rate of central dopaminergic neurons

CF Saller and LA Chiodo

In the rat, doses of glucose sufficient to raise glucose concentrations in the blood to levels equivalent to those produced by a meal or stress suppress the firing of dopamine-containing neurons located within the substantia nigra. Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol.


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