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Science 12 December 1980:
Vol. 210. no. 4475, pp. 1252 - 1253
DOI: 10.1126/science.6254154
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Articles

Science, Vol 210, Issue 4475, 1252-1253
Copyright © 1980 by American Association for the Advancement of Science

articles

Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways

Y Matsuzaki, Y Hamasaki, and SI Said

Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.


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