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Science 5 December 1980:
Vol. 210. no. 4474, pp. 1150 - 1152
DOI: 10.1126/science.7003711
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Articles

Science, Vol 210, Issue 4474, 1150-1152
Copyright © 1980 by American Association for the Advancement of Science

articles

Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation

S Slavin and S Yatziv

Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 X 10(6)) from BALB/c to C3H/HeJ chimeras (>90 percent circulating donor-type cells) without graft versus host disease. beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Donor-derived cells in the central nervous system of twitcher mice after bone marrow transplantation.
P. Hoogerbrugge, K Suzuki, K Suzuki, B. Poorthuis, T Kobayashi, G Wagemaker, and D. van Bekkum (1988)
Science 239, 1035-1038
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Science. ISSN 0036-8075 (print), 1095-9203 (online)