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Science 5 December 1980:
Vol. 210. no. 4474, pp. 1125 - 1126
DOI: 10.1126/science.6777871
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Articles

Science, Vol 210, Issue 4474, 1125-1126
Copyright © 1980 by American Association for the Advancement of Science

articles

Effects of EGTA on the calcium-activated afterhyperpolarization in hippocampal CA3 pyramidal cells

PA Schwartzkroin and CE Stafstrom

Intracellular recordings in the hippocampal slice preparation were made with electrodes filled with 0.2 molar potassium EGTA. The purpose was to investigate the role of calcium in mediating afterhyperpolarizations following bursts evoked by intracellular current pulses, arising spontaneously, or induced by the epileptogenic agent pencillin. In the first two cases the afterhyperpolarization was blocked and the associated conductance increase was reduced, suggesting that EGTA was blocking the calcium-activated potassium conductance during the hyperpolarization. In the third case the afterhyperpolarization and associated conductance increase persisted, implicating an alternative mechanism for the hyperpolarization. ?2Ns 04053


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