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Science 28 November 1980:
Vol. 210. no. 4473, pp. 978 - 984
DOI: 10.1126/science.6254151
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Articles

Science, Vol 210, Issue 4473, 978-984
Copyright © 1980 by American Association for the Advancement of Science

articles

Prostaglandins, arachidonic acid, and inflammation

FA Kuehl Jr and RW Egan

The enzymatic oxidation of arachidonic acid has been shown to yield potent pathological agents by two major pathways. Those of the prostaglandin (PG) pathway, particularly PGE2, have been implicated as inflammatory mediators for many years. The discovery and biological activities of thromboxane A2 and prostacyclin as well as a destructive oxygen-centered radical as additional products of this biosynthetic pathway now require these to be considered as potential inflammatory mediators. Like PGE2, their biosynthesis is prevented by nonsteroidal anti-inflammatory agents. More recently, the alternative metabolic route, the lipoxygenase pathway, has been shown to yield a new class of arachidonic acid oxygenation products, called the leukotrienes, which also appear to be important inflammatory mediators. Unlike the prostaglandins, some of which play important roles as biological regulators, the actions of the lipoxygenase products appear to be exclusively of a pathological nature.


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