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Science 28 November 1980:
Vol. 210. no. 4473, pp. 973 - 978
DOI: 10.1126/science.7434017
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Articles

Science, Vol 210, Issue 4473, 973-978
Copyright © 1980 by American Association for the Advancement of Science

articles

Silent nucleotide substitutions and the molecular evolutionary clock

TH Jukes

Half of the nucleotide substitutions during the evolutionary divergence of genes in animals, bacteria, and viruses are silent changes. These result from an inherent biochemical property of DNA and are fixed by genetic drift. Evolution may be viewed as a device for protecting DNA molecules from extinction.


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Total synthesis and cloning of a gene coding for the ribonuclease S protein.
K. Nambiar, J Stackhouse, D. Stauffer, W. Kennedy, J. Eldredge, and S. Benner (1984)
Science 223, 1299-1301
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