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Science 28 November 1980:
Vol. 210. no. 4473, pp. 1026 - 1028
DOI: 10.1126/science.6254149
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Articles

Science, Vol 210, Issue 4473, 1026-1028
Copyright © 1980 by American Association for the Advancement of Science

articles

Latency of herpes simplex virus in absence of neutralizing antibody: model for reactivation

T Sekizawa, H Openshaw, C Wohlenberg, and AL Notkins

Mice inoculated with herpes simplex virus (type 1) by the lip or corneal route and then passively immunized with rabbit antibody to herpes simplex virus developed a latent infection in the trigeminal ganglia within 96 hours. Neutralizing antibody to herpes simplex virus was cleared from the circulation and could not be detected in most of these mice after 2 months. Examination of ganglia from the antibody-negative mice revealed latent virus in over 90 percent of the animals, indicating that serum neutralizing antibody is not necessary to maintain the latent state. When the lips or corneas of these mice were traumatized, viral reactivation occurred in up to 90 percent of the mice, as demonstrated by the appearance of neutralizing antibody. This study provides a model for identifying factors that trigger viral reactivation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Immune Response to Ocular Herpes Simplex Virus Type 1 Infection.
D. J.J. Carr, P. Härle, and B. M. Gebhardt (2001)
Experimental Biology and Medicine 226, 353-366
   Abstract »    Full Text »
Role for Gamma Interferon in Control of Herpes Simplex Virus Type 1 Reactivation.
E. Cantin, B. Tanamachi, and H. Openshaw (1999)
J. Virol. 73, 3418-3423
   Abstract »    Full Text »
Androstenediol Antagonizes Herpes Simplex Virus Type 1-Induced Encephalitis Through the Augmentation of Type I IFN Production.
J. Daigle and D. J. J. Carr (1998)
J. Immunol. 160, 3060-3066
   Abstract »    Full Text »    PDF »
Establishment of Latent Ganglionic Infection with Herpes Simplex Virus via Maxillary Gingiva and Viral Re-activation in vivo after Trauma.
F. Shimizu, Y. Monma, T. Sekizawa, and K. Kamiyama (1989)
Journal of Dental Research 68, 472-475
   Abstract »    PDF »


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