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Science 28 November 1980:
Vol. 210. no. 4473, pp. 1021 - 1023
DOI: 10.1126/science.7434011
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Articles

Science, Vol 210, Issue 4473, 1021-1023
Copyright © 1980 by American Association for the Advancement of Science

articles

Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

E Canalis, WA Peck, and LG Raisz

Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H]proline collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bone cell differentiation and growth factors.
M. Urist, R. DeLange, and G. Finerman (1983)
Science 220, 680-686
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Science. ISSN 0036-8075 (print), 1095-9203 (online)