Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 November 1980:
Vol. 210. no. 4472, pp. 916 - 918
DOI: 10.1126/science.7192014
Prev | Table of Contents | Next

Articles

Science, Vol 210, Issue 4472, 916-918
Copyright © 1980 by American Association for the Advancement of Science

articles

Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor

EM Johnson Jr, PD Gorin, LD Brandeis, and J Pearson

Rats and guinea pigs, when immunized with mouse nerve growth factor, produce antibodies that cross-react with their own nerve growth factor. The antibodies reach developing offspring of these animals both prenatally (rats and guinea pigs) and postnatally (rats). Depriving the fetus of nerve growth factor in this way results in the destruction of up to 85 percent of dorsal root ganglion neurons as well as destruction of sympathetic neurons. Sensory neurons of placodal origin in the nodose ganglion were not affected. These data demonstrate that dorsal root ganglion neurons go through a phase of nerve growth factor dependence in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Skin as a Neurotrophic Organ.
K. M. Albers and B. M. Davis (2007)
Neuroscientist 13, 371-382
   Abstract »    PDF »
Loss of TRPV1-Expressing Sensory Neurons Reduces Spinal {micro} Opioid Receptors But Paradoxically Potentiates Opioid Analgesia.
S.-R. Chen and H.-L. Pan (2006)
J Neurophysiol 95, 3086-3096
   Abstract »    Full Text »    PDF »
Differential Sensitivity of N- and P/Q-Type Ca2+ Channel Currents to a {micro} Opioid in Isolectin B -Positive and -Negative Dorsal Root Ganglion Neurons.
Z.-Z. Wu, S.-R. Chen, and H.-L. Pan (2004)
J. Pharmacol. Exp. Ther. 311, 939-947
   Abstract »    Full Text »    PDF »
Toward a new generation of vaccines: The anti-cytokine therapeutic vaccines.
D. Zagury, A. Burny, and R. C. Gallo (2001)
PNAS 98, 8024-8029
   Abstract »    Full Text »    PDF »
Defects in Sensory Axon Growth Precede Neuronal Death in Brn3a-Deficient Mice.
S. R. Eng, K. Gratwick, J. M. Rhee, N. Fedtsova, L. Gan, and E. E. Turner (2001)
J. Neurosci. 21, 541-549
   Abstract »    Full Text »    PDF »
Phenotypic Knockout of Nerve Growth Factor in Adult Transgenic Mice Reveals Severe Deficits in Basal Forebrain Cholinergic Neurons, Cell Death in the Spleen, and Skeletal Muscle Dystrophy.
F. Ruberti, S. Capsoni, A. Comparini, E. Di Daniel, J. Franzot, S. Gonfloni, G. Rossi, N. Berardi, and A. Cattaneo (2000)
J. Neurosci. 20, 2589-2601
   Abstract »    Full Text »    PDF »
A Role for HSP27 in Sensory Neuron Survival.
S. E. Lewis, R. J. Mannion, F. A. White, R. E. Coggeshall, S. Beggs, M. Costigan, J. L. Martin, W. H. Dillmann, and C. J. Woolf (1999)
J. Neurosci. 19, 8945-8953
   Abstract »    Full Text »    PDF »
Overexpression of Nerve Growth Factor in Skin Selectively Affects the Survival and Functional Properties of Nociceptors.
C. L. Stucky, M. Koltzenburg, M. Schneider, M. G. Engle, K. M. Albers, and B. M. Davis (1999)
J. Neurosci. 19, 8509-8516
   Abstract »    Full Text »    PDF »
Estrogen receptor-dependent regulation of sensory neuron survival in developing dorsal root ganglion.
C. Patrone, S. Andersson, L. Korhonen, and D. Lindholm (1999)
PNAS 96, 10905-10910
   Abstract »    Full Text »    PDF »
SH2-B, a Membrane-associated Adapter, Is Phosphorylated on Multiple Serines/Threonines in Response to Nerve Growth Factor by Kinases within the MEK/ERK Cascade.
L. Rui, J. Herrington, and C. Carter-Su (1999)
J. Biol. Chem. 274, 26485-26492
   Abstract »    Full Text »    PDF »
Regulation of Neurotrophin Receptor Expression by Retinoic Acid in Mouse Sympathetic Neuroblasts.
S. Wyatt, R. Andres, H. Rohrer, and A. M. Davies (1999)
J. Neurosci. 19, 1062-1071
   Abstract »    Full Text »    PDF »
Developmental Regulation of Apoptosis in Dorsal Root Ganglion Neurons.
M. A. Vogelbaum, J. X. Tong, and K. M. Rich (1998)
J. Neurosci. 18, 8928-8935
   Abstract »    Full Text »    PDF »
Altered regulation of bladder nerve growth factor and neurally mediated hyperactive voiding.
D. B. Clemow, W. D. Steers, R. McCarty, and J. B. Tuttle (1998)
Am J Physiol Regulatory Integrative Comp Physiol 275, R1279-R1286
   Abstract »    Full Text »    PDF »
Purification of a Multipotent Antideath Activity from Bovine Liver and Its Identification as Arginase: Nitric Oxide-Independent Inhibition of Neuronal Apoptosis.
F. Esch, K.-I Lin, A. Hills, K. Zaman, J. M. Baraban, S. Chatterjee, L. Rubin, D. E. Ash, and R. R. Ratan (1998)
J. Neurosci. 18, 4083-4095
   Abstract »    Full Text »    PDF »
Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice.
D. J. Liebl, L. Tessarollo, M. E. Palko, and L. F. Parada (1997)
J. Neurosci. 17, 9113-9121
   Abstract »    Full Text »    PDF »
A Role for TrkA during Maturation of Striatal and Basal Forebrain Cholinergic Neurons In Vivo.
A. M. Fagan, M. Garber, M. Barbacid, I. Silos-Santiago, and D. M. Holtzman (1997)
J. Neurosci. 17, 7644-7654
   Abstract »    Full Text »    PDF »
Receptive Properties of Mouse Sensory Neurons Innervating Hairy Skin.
M. Koltzenburg, C. L. Stucky, and G. R. Lewin (1997)
J Neurophysiol 78, 1841-1850
   Abstract »    Full Text »    PDF »
Disruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits.
K. S. Chen, M. C. Nishimura, M. P. Armanini, C. Crowley, S. D. Spencer, and H. S. Phillips (1997)
J. Neurosci. 17, 7288-7296
   Abstract »    Full Text »    PDF »
The Cyclic AMP Response Element in the Calcitonin/Calcitonin Gene-related Peptide Gene Promoter Is Necessary but Not Sufficient for Its Activation by Nerve Growth Factor.
A. Watson and D. Latchman (1995)
J. Biol. Chem. 270, 9655-9660
   Abstract »    Full Text »    PDF »
Muscle sensory neurons require neurotrophin-3 from peripheral tissues during the period of normal cell death.
R. Oakley, A. Garner, T. Large, and E Frank (1995)
Development 121, 1341-1350
   Abstract »    PDF »
Expression of the BDNF gene in the developing visual system of the chick.
K. Herzog, K Bailey, and Y. Barde (1994)
Development 120, 1643-1649
   Abstract »    PDF »
bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.
D. Merry, D. Veis, W. Hickey, and S. Korsmeyer (1994)
Development 120, 301-311
   Abstract »    PDF »
The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.
D. Kaplan, B. Hempstead, D Martin-Zanca, M. Chao, and L. Parada (1991)
Science 252, 554-558
   Abstract »    PDF »
Flunarizine protects neurons from death after axotomy or NGF deprivation.
K. Rich and J. Hollowell (1990)
Science 248, 1419-1421
   Abstract »    PDF »
The nerve growth factor 35 years later.
R Levi-Montalcini (1987)
Science 237, 1154-1162
   PDF »
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.
W. Mobley, J. Rutkowski, G. Tennekoon, K Buchanan, and M. Johnston (1985)
Science 229, 284-287
   Abstract »    PDF »
Increased numbers of thoracic dorsal root axons in rats given antibodies to nerve growth factor.
C. Hulsebosch, R. Coggeshall, and Perez-Polo JR (1984)
Science 225, 525-526
   Abstract »    PDF »
Nerve growth factor attenuates neurotoxic effects of taxol on spinal cord-ganglion explants from fetal mice.
E. Peterson and S. Crain (1982)
Science 217, 377-379
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)