Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 November 1980:
Vol. 210. no. 4472, pp. 908 - 910
DOI: 10.1126/science.6776628
Prev | Table of Contents | Next

Articles

Science, Vol 210, Issue 4472, 908-910
Copyright © 1980 by American Association for the Advancement of Science

articles

Microencapsulated islets as bioartificial endocrine pancreas

F Lim and AM Sun

Single implantation of microencapsulated islets into rats with streptozotocin-induced diabetes corrected the diabetic state for 2 to 3 weeks. The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Design and Evaluation of a Cell Microencapsulating Device for Cell Assembly Technology.
Rui Yao, Renji Zhang, and Xiaohong Wang (2009)
Journal of Bioactive and Compatible Polymers 24, 48-62
   Abstract »    PDF »
Consistent Liver Metastases in a Rat Model by Portal Injection of Microencapsulated Cancer Cells.
T. Enomoto, T. Oda, Y. Aoyagi, S. Sugiura, M. Nakajima, M. Satake, M. Noguchi, and N. Ohkohchi (2006)
Cancer Res. 66, 11131-11139
   Abstract »    Full Text »    PDF »
Biological and biomaterial approaches for improved islet transplantation..
A. S. Narang and R. I. Mahato (2006)
Pharmacol. Rev. 58, 194-243
   Abstract »    Full Text »    PDF »
Subsieve-size agarose capsules enclosing ifosfamide-activating cells: a strategy toward chemotherapeutic targeting to tumors.
S. Sakai, K. Kawabata, S. Tanaka, N. Harimoto, I. Hashimoto, C. Mu, B. Salmons, H. Ijima, and K. Kawakami (2005)
Mol. Cancer Ther. 4, 1786-1790
   Abstract »    Full Text »    PDF »
Long-Term Graft Function of Adult Rat and Human Islets Encapsulated in Novel Alginate-Based Microcapsules After Transplantation in Immunocompetent Diabetic Mice.
S. Schneider, P. J. Feilen, F. Brunnenmeier, T. Minnemann, H. Zimmermann, U. Zimmermann, and M. M. Weber (2005)
Diabetes 54, 687-693
   Abstract »    Full Text »    PDF »
Tissue Engineering, Stem Cells, and Cloning: Opportunities for Regenerative Medicine.
C. J. Koh and A. Atala (2004)
J. Am. Soc. Nephrol. 15, 1113-1125
   Full Text »    PDF »
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers.
G. A. Silva, C. Czeisler, K. L. Niece, E. Beniash, D. A. Harrington, J. A. Kessler, and S. I. Stupp (2004)
Science 303, 1352-1355
   Abstract »    Full Text »    PDF »
Visualization of the Specific Interaction of Sulfonylurea-Incorporated Polymer with Insulinoma Cell Line MIN6.
K.-H. Park and T. Akaike (2004)
J. Biochem. 135, 179-183
   Abstract »    Full Text »    PDF »
Microencapsulation of Leydig Cells: A System for Testosterone Supplementation.
M. Machluf, A. Orsola, S. Boorjian, R. Kershen, and A. Atala (2003)
Endocrinology 144, 4975-4979
   Abstract »    Full Text »    PDF »
Sodium Alginate as a Scaffold Material for Hepatic Tissue Engineering.
W. J. Wang, X. H. Wang, Q. L. Feng, F. Z. Cui, Y. X. Xu, and X. H. Song (2003)
Journal of Bioactive and Compatible Polymers 18, 249-257
   Abstract »    PDF »
Insulin-Like Growth Factor II Allows Prolonged Blood Glucose Normalization with a Reduced Islet Cell Mass Transplantation.
R. Robitaille, J. Dusseault, N. Henley, L. Rosenberg, and J.-P. Halle (2003)
Endocrinology 144, 3037-3045
   Abstract »    Full Text »    PDF »
The Development of Porous Alginate/Elastin/PEG Composite Matrix for Cardiovascular Engineering.
T. Chandy, G. H. R. Rao, R. F. Wilson, and G. S. Das (2003)
J Biomater Appl 17, 287-301
   Abstract »    PDF »
Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice.
A. Omer, V. F. Duvivier-Kali, N. Trivedi, K. Wilmot, S. Bonner-Weir, and G. C. Weir (2003)
Diabetes 52, 69-75
   Abstract »    Full Text »    PDF »
Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles.
A. D. Dinsmore, M. F. Hsu, M. G. Nikolaides, M. Marquez, A. R. Bausch, and D. A. Weitz (2002)
Science 298, 1006-1009
   Abstract »    Full Text »    PDF »
Nonporous Polyurethane Membranes as Islet Immunoisolation Matrices - Biocompatibility Studies.
S. George, P. D. Nair, M. V. Risbud, and R. R. Bhonde (2002)
J Biomater Appl 16, 327-340
   Abstract »    PDF »
Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane.
V. F. Duvivier-Kali, A. Omer, R. J. Parent, J. J. O'Neil, and G. C. Weir (2001)
Diabetes 50, 1698-1705
   Abstract »    Full Text »    PDF »
In Vitro Effects of Transcatheter Injection on Structure, Cell Viability, and Cell Metabolism in Fibroblast-impregnated Alginate Microspheres.
T. Abruzzo, H. J. Cloft, G. G. Shengelaia, S. M. Waldrop, D. F. Kallmes, J. E. Dion, I. Constantinidis, and A. Sambanis (2001)
Radiology 220, 428-435
   Abstract »    Full Text »    PDF »
Cell encapsulation technology as a therapeutic strategy for CNS malignancies.
T. Visted, R. Bjerkvig, and P. O. Enger (2001)
Neuro-oncol 3, 201-210
   Abstract »    PDF »
Using Selective Withdrawal to Coat Microparticles.
I. Cohen, H. Li, J. L. Hougland, M. Mrksich, and S. R. Nagel (2001)
Science 292, 265-267
   Abstract »    Full Text »
Glucose-stimulated insulin secretion is not obligatorily linked to an increase in O2 consumption in beta HC9 cells.
K. K. Papas and M. A. C. Jarema (1998)
Am J Physiol Endocrinol Metab 275, E1100-E1106
   Abstract »    Full Text »    PDF »
In vitro and in vivo evaluation of insulin-producing beta TC6-F7 cells in microcapsules.
D. Zhou, A. M. Sun, X. Li, S. N. Mamujee, I. Vacek, J. Georgiou, and M. B. Wheeler (1998)
Am J Physiol Cell Physiol 274, C1356-C1362
   Abstract »    Full Text »    PDF »
Prevention of Type I Diabetes and Recurrent {beta}-Cell Destruction of Transplanted Islets.
R. H. Slover and G. S. Eisenbarth (1997)
Endocr. Rev. 18, 241-258
   Abstract »    Full Text »
Tissue engineering.
R Langer and J. Vacanti (1993)
Science 260, 920-926
   Abstract »    PDF »
Applications and Properties of Chitosan.
Q. Li, E.T. Dunn, E.W. Grandmaison, and M.F.A. Goosen (1992)
Journal of Bioactive and Compatible Polymers 7, 370-397
   Abstract »    PDF »
Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets.
P. Lacy, O. Hegre, A Gerasimidi-Vazeou, F. Gentile, and K. Dionne (1991)
Science 254, 1782-1784
   Abstract »    PDF »
New methods of drug delivery.
R Langer (1990)
Science 249, 1527-1533
   Abstract »    PDF »
Artificial Cells as Bioreactive Biomaterials.
T. M. S. Chang (1988)
J Biomater Appl 3, 116-125
   Abstract »    PDF »
Synthesis of Chitosan-Alginate Microcapsule Membranes.
C.A. Mcknight, A. Ku, M.F.A. Goosen, D. Sun, and C. Penney (1988)
Journal of Bioactive and Compatible Polymers 3, 334-355
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)