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Science 21 November 1980:
Vol. 210. no. 4472, pp. 861 - 868
DOI: 10.1126/science.7001628
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Articles

Science, Vol 210, Issue 4472, 861-868
Copyright © 1980 by American Association for the Advancement of Science

articles

Assembly of proteins into membranes

W Wickner

Two pathways for protein assembly into biological membranes have been proposed. The "signal hypothesis" emphasizes the role of specific membrane proteins in binding the growing polypeptide and conducting it into the bilayer during its synthesis. The "membrane-triggered folding" hypothesis emphasizes self-assembly and the role of changing protein conformation during transfer from an aqueous compartment into a membrane. These ideas provide a framework for reviewing recent data on the biogenesis of membrane proteins.


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Cloning, Characterization, and Tissue Expression Pattern of Mouse Nma/BAMBI During Odontogenesis.
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Cloning and Characterization of the cDNA for Human Airway Trypsin-like Protease.
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