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Science 14 November 1980:
Vol. 210. no. 4471, pp. 799 - 801
DOI: 10.1126/science.6254148
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Articles

Science, Vol 210, Issue 4471, 799-801
Copyright © 1980 by American Association for the Advancement of Science

articles

Electroconvulsive shock: progressive dopamine autoreceptor subsensitivity independent of repeated treatment

LA Chiodo and SM Antelman

Repeated electroconvulsive shock, applied to rats, induces a subsensitivity of dopamine autoreceptors located in the substantia nigra as indexed by single-unit electrophysiological techniques. This reduced sensitivity is time-dependent, since effects similar to those seen with repeated treatment were also observed when single electroconvulsive shock was followed by an appropriate treatment-free interval. These data, coupled with identical results after the repeated administration of tricyclic antidepressants, raise the possibility that a reduction of dopamine autoreceptor sensitivity could underlie both electroconvulsive shock and pharmacological treatment of depression.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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G. M. Samoriski and C. D. Applegate (1997)
J. Neurosci. 17, 5581-5590
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Electroconvulsive Treatment and Lithium Carbonate: Their Effects on Norepinephrine Metabolism in Patients With Primary, Major Depressions.
M. Linnoila, F. Karoum, N. Rosenthal, and W. Z. Potter (1983)
Arch Gen Psychiatry 40, 677-680
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Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression.
D. S. Charney, D. B. Menkes, and G. R. Heninger (1981)
Arch Gen Psychiatry 38, 1160-1180
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