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Science 14 November 1980:
Vol. 210. no. 4471, pp. 793 - 794
DOI: 10.1126/science.6449079
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Articles

Science, Vol 210, Issue 4471, 793-794
Copyright © 1980 by American Association for the Advancement of Science

articles

Role of ornithine decarboxylase in cardiac growth and hypertrophy

J Bartolome, J Huguenard, and TA Slotkin

Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.


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