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Science 14 November 1980:
Vol. 210. no. 4471, pp. 791 - 793
DOI: 10.1126/science.6254147
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Articles

Science, Vol 210, Issue 4471, 791-793
Copyright © 1980 by American Association for the Advancement of Science

articles

Visualization of specific angiotensin II binding sites in the brain by fluorescent microscopy

S Landas, MI Phillips, JF Stamler, and MK Raizada

The organum vasculosum of the lamina terminalis has been implicated as the site of receptors mediating central responses of angiotensin II. Up to now, this had been based on indirect evidence, but direct visualization of angiotensin II at its site of action has now been achieved by the use of a biologically active fluorescent angiotensin II agonist. The ventricular surface of the organum vasculosum lamina terminalis showed intense fluorescence, which was virtually eliminated by an excess of unlabeled angiotensin II.


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M. I. Phillips (2004)
Physiol Genomics 18, 1-3
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Intracellular Trafficking of Angiotensin II and its AT1 and AT2 Receptors: Evidence for Selective Sorting of Receptor and Ligand.
L. Hein, L. Meinel, R. E. Pratt, V. J. Dzau, and B. K. Kobilka (1997)
Mol. Endocrinol. 11, 1266-1277
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