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Science 7 November 1980:
Vol. 210. no. 4470, pp. 604 - 610
DOI: 10.1126/science.6254144
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Articles

Science, Vol 210, Issue 4470, 604-610
Copyright © 1980 by American Association for the Advancement of Science

articles

DNA methylation and gene function

A Razin and AD Riggs

In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. However, there is now reason to believe, from recent studies, that DNA methylation is a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.


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