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Science 31 October 1980:
Vol. 210. no. 4469, pp. 539 - 541
DOI: 10.1126/science.7423203
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Articles

Science, Vol 210, Issue 4469, 539-541
Copyright © 1980 by American Association for the Advancement of Science

articles

Antibody targeting of liposomes: cell specificity obtained by conjugation of F(ab')2 to vesicle surface

TD Heath, RT Fraley, and D Papahdjopoulos

A method devised for conjugating liposomes with protein resulted in the binding of up to 200 micrograms of immunoglobulin G per micromole of lipid. The coupling of antibody to human erythrocyte F(ab')2 in vesicles (140 molecules per vesicle) by this method caused a 200-fold increase in the binding of vesticles to human erythrocytes and resulted in about 80 percent of the vesicle lipid and contents being associated with cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
From the Cover: Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers.
F. Gu, L. Zhang, B. A. Teply, N. Mann, A. Wang, A. F. Radovic-Moreno, R. Langer, and O. C. Farokhzad (2008)
PNAS 105, 2586-2591
   Abstract »    Full Text »    PDF »
Immunotargeting of liposomes to activated vascular endothelial cells: A strategy for site-selective delivery in the cardiovascular system.
D. D. Spragg, D. R. Alford, R. Greferath, C. E. Larsen, K.-D. Lee, G. C. Gurtner, M. I. Cybulsky, P. F. Tosi, C. Nicolau, and M. A. Gimbrone Jr. (1997)
PNAS 94, 8795-8800
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)