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Science 24 October 1980:
Vol. 210. no. 4468, pp. 435 - 437
DOI: 10.1126/science.7433984
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Articles

Science, Vol 210, Issue 4468, 435-437
Copyright © 1980 by American Association for the Advancement of Science

articles

Acetylcholine synthesis by displaced amacrine cells

SA Hayden, JW Mills, and RM Masland

The ganglion cell layer of the rabbit retina contains neurons that synthesize acetylcholine. To identify these neurons, the ganglion cells were labeled by retrograde transport of a fluorescent dye, and the acetylcholine-synthesizing cells of the same retinas were labeled by exposing the tissue to tritiated choline. Autoradiographs inspected by fluorescence microscopy showed that tritiated acetylcholine and the dye accumulated in different cells. Optic nerves of other animals were sectioned, causing degeneration of many neurons of the ganglion cell layer. This loss affected neither the retina's overall rate of acetylcholine synthesis nor the number of acetylcholine-containing cells in the ganglion cell layer. The acetylcholine-synthesizing neurons thus appear to be displaced amacrine cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Demonstration of Cholinergic Ganglion Cells in Rat Retina: Expression of an Alternative Splice Variant of Choline Acetyltransferase.
O. Yasuhara, I. Tooyama, Y. Aimi, J.-P. Bellier, T. Hisano, A. Matsuo, M. Park, and H. Kimura (2003)
J. Neurosci. 23, 2872-2881
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Spontaneous Activity in Developing Turtle Retinal Ganglion Cells: Pharmacological Studies.
E. Sernagor and N. M. Grzywacz (1999)
J. Neurosci. 19, 3874-3887
   Abstract »    Full Text »    PDF »
Direct Participation of Starburst Amacrine Cells in Spontaneous Rhythmic Activities in the Developing Mammalian Retina.
Z. J. Zhou (1998)
J. Neurosci. 18, 4155-4165
   Abstract »    Full Text »    PDF »
Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture.
D Leifer, S. Lipton, C. Barnstable, and R. Masland (1984)
Science 224, 303-306
   Abstract »    PDF »


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