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Science 24 October 1980:
Vol. 210. no. 4468, pp. 429 - 431
DOI: 10.1126/science.7433982
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Articles

Science, Vol 210, Issue 4468, 429-431
Copyright © 1980 by American Association for the Advancement of Science

articles

Tumor promoter TPA mimics irradiation effects on the cell cycle of HeLa cells

V Kinzel, J Richards, and M Stohr

When asynchronous and synchronous HeLa cells were incubated with small doses (10(-7) M) of tumor promoter 12 O-tetradecanoylphorbol-13-acetate (TPA), a variety of transient alterations in the replication cycle were detected within 24 hours by the use of independent methods. Especially, a delayed passage through the S phase and influences on the G2 phase resemble x-ray irradiation effects on cell cultures. None of these alterations was observed with the hyperplasiogenic but nonpromoting 4-O-methyl-TPA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of the Expression of Differentiation-Related Antigens on Human Colon Carcinoma Cells by Stimulating Protein Kinase C.
P. L. Baron, MichaelJ. Koretz, R. A. Carchman, J. M. Collins, A. S. Tokarz, and G. A. Parker (1990)
Arch Surg 125, 344-350
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