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Science 17 October 1980:
Vol. 210. no. 4467, pp. 340 - 342
DOI: 10.1126/science.7423197
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Articles
Science, Vol 210, Issue 4467, 340-342
Copyright © 1980 by American Association for the Advancement of Science
Rapid effect of triiodothyronine on the mitochondrial pathway in rat liver in vivo
K Sterling,
MA Brenner,
and
T Sakurada
Intravenous infections of minute doses of triiodothyronine were administered to thyroidectomized rats 30 minutes before they were killed. Hepatic mitochondria were isolated rapidly and formation of adenosine triphosphate and consumption of oxygen were assessed by a 2-minute incubation. Hormone injection enhanced formation of adenosine triphosphate 114 to 217 percent over control values, with a proportionate increase in consumption of oxygen. The ratio of phosphate to oxygen was about 2.0, signifying tightly coupled oxidative phosphorylation. Stimulation was not abolished by injection of cycloheximide, puromycin, actinomycin D, or chloramphenicol 1 hour before the rats were killed. This signifies direct mitochondrial stimulation by triiodothyronine in the absence of protein synthesis.
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