Related Content
Search Google Scholar for:
|
|
Science 17 October 1980:
Vol. 210. no. 4467, pp. 340 - 342
DOI: 10.1126/science.7423197
|
|
Articles
Science, Vol 210, Issue 4467, 340-342
Copyright © 1980 by American Association for the Advancement of Science
Rapid effect of triiodothyronine on the mitochondrial pathway in rat liver in vivo
K Sterling,
MA Brenner,
and
T Sakurada
Intravenous infections of minute doses of triiodothyronine were administered to thyroidectomized rats 30 minutes before they were killed. Hepatic mitochondria were isolated rapidly and formation of adenosine triphosphate and consumption of oxygen were assessed by a 2-minute incubation. Hormone injection enhanced formation of adenosine triphosphate 114 to 217 percent over control values, with a proportionate increase in consumption of oxygen. The ratio of phosphate to oxygen was about 2.0, signifying tightly coupled oxidative phosphorylation. Stimulation was not abolished by injection of cycloheximide, puromycin, actinomycin D, or chloramphenicol 1 hour before the rats were killed. This signifies direct mitochondrial stimulation by triiodothyronine in the absence of protein synthesis.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Thyroid Hormone Activates Adenosine 5'-Monophosphate-Activated Protein Kinase via Intracellular Calcium Mobilization and Activation of Calcium/Calmodulin-Dependent Protein Kinase Kinase-{beta}.
- M. Yamauchi, F. Kambe, X. Cao, X. Lu, Y. Kozaki, Y. Oiso, and H. Seo (2008)
Mol. Endocrinol.
22, 893-903
| Abstract »
| Full Text »
| PDF »
- Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo.
- I. Irrcher, D. R. Walkinshaw, T. E. Sheehan, and D. A. Hood (2008)
J Appl Physiol
104, 178-185
| Abstract »
| Full Text »
| PDF »
- Direct action of T3 on phosphorylation potential in the sheep heart in vivo.
- M. A. Portman, K. Qian, J. Krueger, and X.-H. Ning (2005)
Am J Physiol Heart Circ Physiol
288, H2484-H2490
| Abstract »
| Full Text »
| PDF »
- Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptor.
- N. Saelim, L. M. John, J. Wu, J. S. Park, Y. Bai, P. Camacho, and J. D. Lechleiter (2004)
J. Cell Biol.
167, 915-924
| Abstract »
| Full Text »
| PDF »
- Physiological and Molecular Basis of Thyroid Hormone Action.
- P. M. Yen (2001)
Physiol Rev
81, 1097-1142
| Abstract »
| Full Text »
| PDF »
- A Variant Form of the Nuclear Triiodothyronine Receptor c-ErbAalpha 1 Plays a Direct Role in Regulation of Mitochondrial RNA Synthesis.
- F. Casas, P. Rochard, A. Rodier, I. Cassar-Malek, S. Marchal-Victorion, R. J. Wiesner, G. Cabello, and C. Wrutniak (1999)
Mol. Cell. Biol.
19, 7913-7924
| Abstract »
| Full Text »
| PDF »
- Direct Regulation of Mitochondrial RNA Synthesis by Thyroid Hormone.
- J. A. Enriquez, P. Fernandez-Silva, N. Garrido-Perez, M. J. Lopez-Perez, A. Perez-Martos, and J. Montoya (1999)
Mol. Cell. Biol.
19, 657-670
| Abstract »
| Full Text »
| PDF »
- Nutrient–gene interactions determine mitochondrial function: effect of dietary fat.
- M. Kim and C. D. Berdanier (1998)
FASEB J
12, 243-248
| Abstract »
| Full Text »
- A 43-kDa Protein Related to c-Erb A [IMAGE]1 Is Located in the Mitochondrial Matrix of Rat Liver.
- C. Wrutniak, I. Cassar-Malek, S. Marchal, A. Rascle, S. Heusser, J.-M. Keller, J. Fléchon, M. Daua, J. Samarut, J. Ghysdael, et al. (1995)
J. Biol. Chem.
270, 16347-16354
| Abstract »
| Full Text »
| PDF »
|
|
