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Science 17 October 1980:
Vol. 210. no. 4467, pp. 329 - 330
DOI: 10.1126/science.7423193
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Articles

Science, Vol 210, Issue 4467, 329-330
Copyright © 1980 by American Association for the Advancement of Science

articles

Genotoxicity of the antihypertensive drugs hydralazine and dihydralazine

GM Williams, G Mazue, CA McQueen, and T Shimada

The genotoxicity of the antihypertensive agents hydralazine and dihydralazine was tested in mammalian cells and bacteria. Both drugs elicited DNA repair in rat hepatocyte primary cultures. In the Ames test, both with and without an S-9 fraction, hydralazine was mutagenic in strains TA100 and TA1537, whereas dihydralazine was weakly mutagenic in strain TA1537. These findings support the observation that hydralazine is carcinogenic in mice. The carcinogenicity of many chemicals results from interaction with DNA. Since these studies demonstrate that hydralazine and dihydralazine damage DNA in mammalian cells, these drugs should be viewed as potential human carcinogens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evaluation of antimutagenic effect of todralazine in cultured lymphocytes.
K. Gasiorowski and B. Brokos (2000)
Mutagenesis 15, 137-141
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