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Science 10 October 1980:
Vol. 210. no. 4466, pp. 210 - 211
DOI: 10.1126/science.7191143
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Articles

Science, Vol 210, Issue 4466, 210-211
Copyright © 1980 by American Association for the Advancement of Science

articles

Mediation of diurnal fluctuations in pain sensitivity in the rat by food intake patterns: reversal by naloxone

RF McGivern and GG Berntson

Rats maintained on a 12-hour light-dark cycle were tested for pain sensitivity after being deprived of food during either the dark or the light phase of the cycle. Diurnal fluctuations in pain sensitivity were observed. The fluctuations followed food intake patterns rather than a natural circadian rhythm, with food deprivation producing a decrease in pain sensitivity. The analgesic response produced by this mild food deprivation was strongly attenuated by naloxone or feeding, suggesting that endogenous opioid systems may be related to patterns of food intake.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hypotensive effect of fasting: possible involvement of the sympathetic nervous system and endogenous opiates.
D Einhorn, J. Young, and L Landberg (1982)
Science 217, 727-729
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