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Science 10 October 1980:
Vol. 210. no. 4466, pp. 195 - 198
DOI: 10.1126/science.6774420
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Articles

Science, Vol 210, Issue 4466, 195-198
Copyright © 1980 by American Association for the Advancement of Science

articles

Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats

GD Lux, LJ Marton, and SB Baylin

A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the newborn rat in the third week after birth. During this period, there is a rapid conversion of the mucosa from a fetal to a mature adult status. A similar increase in ornithine decarboxylase activity also accompanies the rapid recovery of the mucosa 1 week after an injury is induced by chemotherapy in adult rats. In vivo, alpha-difluoromethyl ornithine, a highly selective, enzyme-activated, irreversible inhibitor, suppresses these increases in mucosal ornithine decarboxylase and delays both intestinal mucosal maturation and recovery from injury. Thus increased ornithine decarboxylase activity, with the resultant increase in polyamine content, may play an essential role in intestinal mucosal maturation and regeneration in the rat.


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Differentiated intestinal epithelial cells exhibit increased migration through polyamines and myosin II.
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Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis.
L. Li, J. Li, J. N. Rao, M. Li, B. L. Bass, and J.-Y. Wang (1999)
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Expression of the transforming growth factor-beta gene during growth inhibition following polyamine depletion.
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Short-Chain Fatty Acids Increase Proglucagon and Ornithine Decarboxylase Messenger RNAs After Intestinal Resection in Rats.
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Relationship of Jejunostomy and Urine Polyamine Content to Refeeding and Intestinal Structure and Function.
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