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Science 3 October 1980:
Vol. 210. no. 4465, pp. 93 - 95
DOI: 10.1126/science.6774418
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Articles

Science, Vol 210, Issue 4465, 93-95
Copyright © 1980 by American Association for the Advancement of Science

articles

Antireproductive effects of a potent gonadotropin-releasing hormone antagonist in the male rat

C Rivier, J Rivier, and W Vale

Administration of a potent antagonist of gondadotropin-releasing hormone (GnRH) antagonist [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-N alpha-MeLeu7-GnRH to adult male rats for 2 weeks resulted in decreased testosterone production and sexual organ weights and in disrupted spermatogenesis. The results demonstrate the essential role of gonadotropin-releasing hormone in the maintenance of reproductive functions and have implications for the regulation of male fertility.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pituitary receptor site blockade by a gonadotropin-releasing hormone antagonist in vivo: mechanism of action.
D Heber, R Dodson, R. Swerdloff, K Channabasavaiah, and J. Stewart (1982)
Science 216, 420-421
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